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Hi Matt, We have 3 papers out but I think I cannot send you personal author pdf because they are not published as Open paper. I added the links below. The first link should be of interest since we found dramatic negative effect of low does of atrazine on Xenopus tadpoles and metamorphic anti-ranaviral immunity. Jacques http://www.ncbi.nlm.nih.gov/pubmed/24984115 http://www.ncbi.nlm.nih.gov/pubmed/24898512 http://www.ncbi.nlm.nih.gov/pubmed/24623410 On 7/10/14, 10:44 AM, "Gray, Matthew James" <[log in to unmask]> wrote: GRC: A new publication and press release below on ranaviruses. Also, a reminder that the GRC Board attempts to maintain a current list of ranavirus publications on the GRC website; here is the current list for 2014: http://fwf.ag.utk.edu/mgray/ranavirus/2014Publications.htm <https://urldefense.proofpoint.com/v2/url?u=http-3A__fwf.ag.utk.edu_mgray_ranavirus_2014Publications.htm&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=9G-0gXLlt5MKIEHc7LUUck7n3aswbiD6XOq04_Wmvvo&e=> As you publish papers, please send an email to Amanda or me so we can add it to the website. As promised, our website will be updated soon. Jesse is working with our website designer (Dr. Peter Bouwma), and hope to have it live in August. As mentioned previously, we plan to offer membership to the GRC once it is live, and those that join in 2014 will be deemed "charter members." Also, Tom Waltzek and Jim Wellehan at University of Florida are beginning the initial planning phases of the 2015 International Symposium on Ranaviruses. If you would like to be involved in planning or help with activities during the symposium, please contact Tom or Jim. All the Best, Matt ______________________________________________________________ Matthew J. Gray, Ph.D., Professor Director, Global Ranavirus Consortium <https://urldefense.proofpoint.com/v2/url?u=http-3A__fwf.ag.utk.edu_mgray_ranavirus_Ranavirus.htm&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=Th7M1GNdsL6qWqlbA18iLJecnFqUahY_nem9OYldA-U&e=> Associate Director, Center for Wildlife Health University of Tennessee 274 Ellington Plant Sciences Building Knoxville, TN 37996-4563 865.974.2740 [ofc] [log in to unmask] <https://urldefense.proofpoint.com/v2/url?u=http-3A__mailto-3Amattjgray-40utk.edu&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=rrICGWJN7OWaobtMQ8k3B2Z5Smw8LgkG6hcVtTjV400&e=> 865.974.4714 [fax] http://fwf.ag.utk.edu/personnel/mgray.htm <https://urldefense.proofpoint.com/v2/url?u=http-3A__fwf.ag.utk.edu_personnel_mgray.htm&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=LWv-hz3pQAYluvNLfGVGblzd-2bJs3U_cfouXgwqbZk&e=> For more information about Forestry, Wildlife and Fisheries at UTK, Please visit http://fwf.ag.utk.edu/ <https://urldefense.proofpoint.com/v2/url?u=http-3A__fwf.ag.utk.edu_&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=HE6M3JE4NyNfSEGtDuYmzlEsTu3rl7xAGkGqtRf0v4k&e=> or call 865.974.7126 _____________________________________________________________ From: UT News Sent: Wednesday, July 09, 2014 1:48 PM Subject: Study Predicts Ranavirus as Potential New Culprit in Amphibian Extinctions [cid:3487834854_1293735] July 9, 2014 Study Predicts Ranavirus as Potential New Culprit in Amphibian Extinctions KNOXVILLE-Amphibian declines and extinctions around the world have been linked to an emerging fungal disease called chytridiomycosis, but new research from the National Institute for Mathematical and Biological Synthesis (NIMBioS) and the Center for Wildlife Health at the University of Tennessee, Knoxville, shows that another pathogen, ranavirus, may also contribute. In a series of mathematical models, researchers showed that ranavirus, which causes severe hemorrhage of internal organs in frogs, could cause extinction of isolated populations of wood frogs if they are exposed to the virus every few years, a scenario that has been documented in wild populations. The most widely distributed amphibian species in North America, wood frogs have been shown to be highly susceptible to ranavirus infection, particularly as tadpoles. But little research has been done into how ranavirus affects frogs at all stages of their life cycle-from egg to hatchling to tadpole to metamorph, the stage when they emerge as frogs. Little is also known about how the infection could hasten extinction in entire populations. The study, published in the journal EcoHealth, investigates the effect of ranavirus on the entire life cycle of wood frogs in demographically isolated populations, where there is no movement of frogs into the population from surrounding areas. The study can be found by visiting http://bit.ly/1r8ivPF <https://urldefense.proofpoint.com/v2/url?u=http-3A__bit.ly_1r8ivPF&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=C1y7aA960lawsv-lOf0s11aORbtLq-IRMZIXKX_x6Jc&e=> . The study used mathematical simulations based on long-term data sets from wild populations of wood frogs in the eastern United States and laboratory data on the effects of ranavirus. It determined that the life stage during which frogs were exposed to ranavirus was one of the most important factors in predicting extinction and declines. Extinction was most likely to occur when tadpoles or metamorphs were exposed to ranavirus at frequent intervals in small populations. Under the worst-case scenario, extinction could occur in as quickly as five years with exposure every year and 25-44 years with exposure every two years. The egg stage had a 57 percent survival rate when exposed to ranavirus, which was high enough to prevent extinction. Scientists speculate that eggs have a greater survival rate than other stages because they are protected by a thick gelatinous membrane that may serve as a structural barrier or contain antiviral properties. "Just as the chytrid fungus has decimated frog populations, the results of our study suggest that ranavirus infection, too, could contribute to extinction of amphibian populations that are demographically isolated," said lead author and NIMBioS postdoctoral fellow Julia Earl. Amphibians are already considered the most imperiled of vertebrates, and a third of amphibians are threatened or endangered, according to the International Union for Conservation of Nature, the main international body that assesses the conservation status of species. Disease also may be playing a role in amphibians' extinction. Since the 1990s, chytridiomycosis, which has been called the worst disease affecting vertebrate animals in recorded history, has caused massive die-offs and species extinctions around the world, particularly in Australia; the Caribbean; and North, Central and South America. "Ranavirus infections in amphibians have been known since the 1960s, but it wasn't until the 1980s when we started to see large-scale die-offs," said collaborating UT scientist and director of the Global Ranavirus Consortium, Matthew Gray, "Hypothesized mechanisms for emergence include global transport of novel virus strains during the commercial trade of cold-blooded animals and an increase in anthropogenic stressors, such as pesticides, on the landscape." Once exposed to ranavirus, in susceptible species like wood frogs, mortality can be as quick as three days. Transmission can occur through water, direct contact and tadpoles scavenging other dead and infected frogs. There is no cure or treatment for the disease. The National Institute for Mathematical and Biological Synthesis is an NSF-supported center that brings together researchers from around the world to collaborate across disciplinary boundaries to investigate solutions to basic and applied problems in the life sciences. To learn more, visit http://www.nimbios.org <https://urldefense.proofpoint.com/v2/url?u=http-3A__www.nimbios.org&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=5Ffvmodv1XEIt55zDcip12Gj00As9HCD9dRoMRVkcWo&e=> . To learn more about this research, visit http://www.nimbios.org/press/FS_frogs <https://urldefense.proofpoint.com/v2/url?u=http-3A__www.nimbios.org_press_FS-5Ffrogs&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=85RxRgg3ZxAn0xldNq2P9iH_T1T-DxQ-bhunnnqJhCw&e=> . --- CUTLINE: Wood frog tadpole hemorrhage from a die-off in Brunswick, Maine, in which it is estimated more than 200,000 tadpoles died in less than 24 hours due to ranavirus. Photo credit: Nathaniel Wheelwright. --- C O N T A C T: Catherine Crawley (865-974-9350, [log in to unmask]) Whitney Heins (865-974-5460, [log in to unmask] <https://urldefense.proofpoint.com/v2/url?u=http-3A__mailto-3Awheins-40utk.edu&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=pJw1FhbzrFI9RB7mQ26_SVBvheyfB7GjMSYFL-HtCSM&e=> ) For more UT news, visit http://tntoday.utk.edu <https://urldefense.proofpoint.com/v2/url?u=http-3A__tntoday.utk.edu&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=IM_GiEbPzOYR1HXpMb_JzJtJ0Rxe0ztOMjDP_QHxMv4&e=> . See UT faculty, staff and students making news at http://tntoday.utk.edu/category/in-the-news <https://urldefense.proofpoint.com/v2/url?u=http-3A__tntoday.utk.edu_category_in-2Dthe-2Dnews&d=AAMF-g&c=4sF48jRmVAe_CH-k9mXYXEGfSnM3bY53YSKuLUQRxhA&r=2JaCEt3mneG2boH2uBtt2czP8V4-1REsQptNpn4znv8aPchkdecnCTOsh_RMKMwP&m=xlFCaqGsrJEJs0nEnTdrMAHu-4QesLqN1-va-Puieb8&s=hxYV2y9yo6XYM_XBaMxYcrRX5yS_8_3wZwV4tWjsCyQ&e=> . -- Jacques ROBERT, Ph. D. Associate Professor of Microbiology and Immunology Undergraduate Track Coordinator and Advisor for the BMB Concentration, UPBM Program Director of the BS/MS IMV graduate program Director of the Xenopus laevis Research Resource for Immunobiology Department of Microbiology & Immunology, Box 672 University of Rochester , Medical Center Room 2-11124, MRBX Rochester, NY 14642 USA Phone: office: (585) 275-1722; lab: (585) 275-5359 FAX: (585) 473-9573 Email: [log in to unmask] http://www.urmc.rochester.edu/smd/mbi/faculty/robert.htm http://www.urmc.rochester.edu/mbi/resources/labs/Robert_Lab/index.cfm Xenopus laevis Resource for Immunobiology: http://www.urmc.rochester.edu/smd/mbi/xenopus/index.htm Use of the return email address on this message for commercial purposes is prohibited. The transmission of unsolicited commercial material is prohibited under federal laws (47 USC 227). Civil penalties and claims of $500.00 per occurrence (47 USC 227[c]) may be assessed for violations.